12/30/2023 0 Comments Dp116 sparkle and co![]() RNA was extracted from these cells using High Pure RNA isolation kits (Roche Diagnostics). Louis, MO, USA) and collected using the lysis/binding buffer from High Pure RNA isolation kits (Roche Diagnostics, Basel, Switzerland). Identification of Dp116 in U-251 cells facilitates studies on the roles of Dp116.Ĭultured cells were rinsed twice with phosphate buffered saline (PBS Sigma-Aldrich Co., St. Splicing patterns of DMD exons were compared in Dp116 and Dp71. Furthermore, five splice variants and two novel splicing patterns of the DMD gene were identified. ![]() Dp116 mRNA and protein were shown to be expressed in glioblastoma cells. This study was designed to characterize Dp116 and the alternative splicing of DMD exons in glioblastoma cells. We previously showed that glioblastoma cells express Dp71, with this Dp71 composed of six splice variants, suggesting that glioblastoma provides a specific environment for regulating the splicing of DMD exons.ĭuring the study on Dp71, we have obtained a signature that indicates the expression of Dp116 in U-251 cells. The DMD gene is regarded as a tumor suppressor gene, with Dp71 shown to have tumor suppressive activity. One method of treatment may be the manipulation of RNA processing of tumor drivers. Molecular characterization of glioblastoma may help in designing effective therapies. Glioblastoma is an aggressive brain tumor highly resistant to treatment. Analysis of Dp71 transcripts has identified multiple exon skipping patterns in the region from exon 71 to exon 78. Though most skipping of DMD exons occurs in-frame exons, skipping of exon 78 shifts the reading frame to produce a large dystrophin with an elongated C-terminal amino acid sequence. The most frequent type of alternative splicing of the DMD gene consists of the skipping of exons. Īlternative splicing is a mechanism that enables cells to generate various diverse proteins from a limited number of genes, as well as having important physiological functions in different developmental processes in humans. It is necessary to understand physiological roles of Dp116 well, since cardiomyopathy is a leading cause of early death in DMD. However, exact mechanism of Dp116 to enhance cardiomyopathy remains unknown. We recently reported that Dp116 plays a role in the development of cardiac dysfunction in DMD patients, suggesting that Dp116 expression is not limited to Schwann cells. Due to its limited expression and large size, the pathophysiological roles of Dp116 are largely unknown. The Dp116 promoter is characterized by its very specific activation in Schwann cells. Dp116 transcript is 5.2 kb long and consists of the Dp116-specific exon S1 joined to DMD exons 56–79. Thus, DMD exons 63–79 are incorporated into the mRNA of not only Dp71 but also all other isoforms.ĭp116, the second shortest isoform of the DMD gene, is transcribed from the Dp116 promoter in intron 55. ![]() Dp71, the shortest isoform, is transcribed from a promoter in intron 62 of the DMD gene, with the Dp71 transcript consisting of Dp71-specific exon G1 and DMD exons 63–79. Four alternative promoter-first exon regions are embedded in downstream introns and produce the Dp260, Dp140, Dp116 and Dp71 isoforms. Dp427 m is a full-length muscle-specific isoform, a lack of which causes Duchenne muscular dystrophy (DMD) (OMIM310200), a fatal progressive muscle wasting disease. The gene exhibits a highly complex arrangement, with eight alternative promoters scattered in its introns driving the expression of four full-length and four short dystrophin isoforms in a tissue- or development-specific manner. The DMD gene is one of the largest genes in the human genome, encoding a 14-kb long transcript consisting of 79 exons spread over more than 2.4 Mb on the X chromosome. However, the splicing patterns in glioblastoma cells of DMD exons in Dp116 and Dp71 showed no significant differences. Two novel splicing patterns were also observed, one with a deletion of exons 68 and 69 (Dp116bΔ68-69) and the other with a 100 bp deletion in the 5’ terminal end of exon 75 (75s), which was produced by the activation of a cryptic splice acceptor site (Dp116b75s). A third transcript lacking exons 71–74 and 78 was also identified (Dp116bc). The most abundant transcript lacked only exon 78 (Dp116b), whereas the second most abundant transcript lacked both exons 71 and 78 (Dp116ab). Sequencing of the amplified product revealed five splice variants, all skipping exon 78. Western blotting of U-251 cell lysates revealed a signal at a position corresponding to vector-expressed Dp116 protein, indicating that Dp116 is expressed in glioblastoma cells. ![]() The full-length Dp116 transcript was amplified as nearly 3 kb in size. Full-length Dp116 cDNA, extending from exon S1 to exon 79, was PCR amplified to avoid confusion with other DMD isoforms.
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12/30/2023 0 Comments Arduino bluetooth remote![]() It thereby proves that it will be useful in an environment that is hazardous to human being. Our evaluation of the system shows that the robotic car for picking and placing small objects within a limited distance performed according to specification. The robotic car will move in the appropriate direction sent to him by the operator through the Bluetooth for execution. The method adopted in this study uses DC motor to move the robotic vehicle to the appropriate direction using commands. If not, you'll have to learn Android programming. Our proposed system works by using a Bluetooth module for receiving the Bluetooth command being sent by the operator. You'll need an Android APP to interface with the bluetooth and receive instructions to control the camera. A prototype of a robotic vehicle for pick and place have been designed and implemented in this study. So, there is a need for a machine that will not be affected by these during the course of carrying out the human-like tasks. In such circumstances, without a considerable amount of safety precautions like in the disposal of hazardous wastes, radioactive substances, remote handling of explosive devices and righting and hostage situations among others, work is impossible. There are several environmental conditions under which human beings do not find conducive to work. ![]() This project can be made in a bigger scale for real time vehicles. The remote can be any android or IOS cell phones. This is a very simple and easy type form of remote control car, where the ordinary microcontroller has been replaced by Arduino and IR sensors has been replaced by a Bluetooth module. The microcontroller then transmits the signal to the motor driver IC’s to operate the motors. Robot has a Bluetooth receiver unit which receives the commands and gives it to the microcontroller circuit to control the motors. User can use various commands like move forward, reverse, move left, move right using these commands which are sent from the Android mobile. The wireless communication techniques used to control the robot is Bluetooth technology. ![]() Then user needs to turn on the Bluetooth in the mobile. The motor speed is controlled by using a digital output and a value in the range 0 to 255. The Arduino reads the Potentiometer value as a number in the range 0 to 1023, so thats the input range. For this the android mobile user has to install an application on her/his mobile. The motor speed is controlled by the Potentiometer connected to A0. The control commands available are more than RF modules. ![]() The irrecv.blink13 (true) function on line 11 will blink the Arduino’s on board LED every time the receiver gets a signal from the remote control, which is useful for debugging. But this project makes use of Android mobile phone for robotic control. Next we start the IR receiver by calling the IRrecv member function enableIRIn () (line 10). If you have an idea leave it below or contact us.Many of the wireless-controlled robots use RF modules. Next in line are accelerometer control and if-statement controlled Data-sends for received response from the Arduino Device being controlled. Suggestions on next features to add are welcome. Set what Data string sends when each button is Pressed/Released (you can also leave onRelease() blank to send null) New features continually added, newest feature is Speech Recognition Send data as String format to your boards with whatever you programmed your Arduino to recognize and Receive data back in the Serial Monitor below Or keep it simple and turn an LED on with nothing but your voiceĪutomatically searches for Bluetooth Devices and Bluetooth-enabled Arduino boards or boards with a bluetooth module attached Send/Recieve Data - now even with custom voice commands utilizing speech recognition for keywords set by the user High-end, customizable, Bluetooth control for Arduino ProjectsĬonnect to and control your Arduino project with this easy-to-use Bluetooth Serial Monitor + Controller 12/30/2023 0 Comments Entrepreneur daily schedule example![]() Put “C” requirements in their proper place.Attend to them after you’ve worked on an “A” responsibility. For most people, “B” responsibilities represent another 30% to 40% of work time. “B” responsibilities might include corresponding with clients, handling claims, supervising staff, inputting data, checking contracts, shipping materials or updating a database. “B” activities are the activities in your job description that must get done today – the tasks that keep you busy. Take care of your “B” responsibilities.These top-priority items should take up 20% to 30% of your time. “A” priorities might include hiring a new account manager, developing a major proposal or opening a new branch location. What would affect your long-term results? The answers are your “A” priorities: important activities that move along your primary endeavors. No meetings, no calls, no reports – nothing. Ask yourself what your main focus would be if you had nothing else to do tomorrow. Improving productivity means spending time on the right things, starting with planning. Rank your responsibilities with the ABCD task-management method. Rank your responsibilities and plan your week accordingly. This ensures that critical business elements get addressed and that your time is well spent. Take a systematic approach to organizing your tasks and managing your time. By prioritizing tasks with the highest return on investment, your business can see tremendous growth.” How an entrepreneur should prioritize tasks “By wasting time on tasks that do not yield results in growth for your business, you might find your business stagnant. “You only have so much time during your day to get things done,” said Forrest McCall, owner of an entrepreneurship blog Don’t Work Another Day. “As a result, it’s critical to organize your time in order to be the most effective and move your company faster.”įor the health of their business – and their personal well-being – entrepreneurs must get a handle on what needs to get done when it needs to happen, and to whom they can delegate. “As an entrepreneur, more than any other role, you have limited time to accomplish a never-ending list of tasks and to-dos,” said Felipe Zambrano, vice president of Avatrade Marketplace. If you’re overwhelmed, you’re more likely to overlook critical tasks and miss deadlines. Why entrepreneurs should prioritize tasksĮntrepreneurs are responsible for myriad aspects of starting a business, such as creating a business plan, writing a marketing plan, creating a successful hiring process, and managing finances. Take steps to prevent burnout before it sets in. ![]() Learn more about reducing stress when working from home in our article: Dealing with stress, anxiety and isolation when you work from home.Burnout can lead to job dissatisfaction, inefficient decision-making, depression and even heart disease. However, it’s essential to use this flexibility wisely and build morning and evening routines that will make your working day more productive and improve your work-life balance. The great thing about being an entrepreneur is the flexibility it can offer you. You could also incorporate some time before bed to reduce screen time as notifications and social media release dopamine, making it more difficult to sleep. You could also create a to-do list that evening, so you know exactly what you want to focus on in the morning. One great way to switch off is to do a brain dump of all the tasks you need to complete the following day and prioritise them. Evening routines: are crucial for entrepreneurs to switch off from work, improve sleep, and enjoy a healthy work-life balance.You could also build a mindful morning routine to reduce stress levels and to get you in the right mindset for the day. It can be a great source of quiet time to focus and get important tasks done. Morning routines: Many entrepreneurs like to get up early to avoid distractions that generally happen throughout the day.The most important routines to build are your morning and evening routines. Routines can help you schedule your days and improve productivity. 12/30/2023 0 Comments Hand of fate cursed treasure![]() You are welcome to the treasure, says a wizened old monk, but know that it is. Try to trap the creature with a Knight blocker and possibly some Wild Growths.Ġ-150? gp, 0-5? Platinum Coins, 0-4 Small Sapphires, Cape, Mind Stone, Emerald Bangle, 0-4 Concentrated Demonic Blood, Demonic Essence (semi-rare), Platinum Amulet (semi-rare), Wand of Inferno (semi-rare), Knight Armor (semi-rare), Skull Staff (semi-rare), Gold Ingot (rare), Crown Armor (rare), Violet Gem (very rare), Golden Figurine (very rare), Abyss Hammer (very rare). In the courtyard of a remote, run-down temple you find a pile of treasure. ![]() Cursed be him that doubts Thy virtue I have tried it, and declare. Note though that when using Haste, the creature can become extremely fast, about the speed of a level 650+ so don't expect to chase it until it has slowed down. treasure too ) with youth so fierce Where's Theodore THEO. So, that Knight must try to lure it in a place where it can't move, and then spam it with Ice and Holy-Based Spells. The wiki seems to say its unlocked by a token via the Giant Eagle, but I cant find that card either. ![]() This may be tricky though since it can disappear, and you have to find it with Runes. I cant seem to find Cursed Treasure, or whatever that cursed treasure-chest was called, anymore. Since it has no ranged damaging attack, it is a good idea to have a Knight blocking it and as many shooters as possible. Pits of Inferno, The Battlefield, The Arcanum, The Blood Halls and The Crystal Caves. The Hand of Cursed Fate's boss is The Handmaiden. Both parties create their own decks of cards. It has the ability to deal high amounts of damage and can also Mana Drain making it one of the most dangerous creatures in Tibia. Like its predecessor, Hand of Fate 2 is a cross between a card game, a board game, an RPG, a dungeon crawler, and a Choose Your Own Adventure story, with 3D combat. Depending on what is chosen, a different event occurs. The wiki seems to say it's unlocked by a token via the Giant Eagle, but I can't find that card either. A chance event consists of four cards that are shown to the player face up. I can't seem to find Cursed Treasure, or whatever that cursed treasure-chest was called, anymore. Encounters can consist of combat, a chance event, or both. Most have a token that can be won by overcoming the challenge presented to the player. This creature was implemented in the Winter Update 2006. Encounters are the main game card of Hand of Fate. Hand of Cursed Fate runs in low green health.Ī demonic minion with sole purpose to bring pain and despair to all who enter its domain. So I must have lain for hours, continually beaten. Melee (0-520 poisons you up to 19 Hitpoints per turn), Mana Drain (0-920+), Life Drain (0-880+), Invisibility, Strong Haste, Self-Healing, causes Drunkennessĩ20+ Mana Drain per turn and 1400+ hp per turnĭeath, Fire, Energy, Earth, Invisibility, Paralyze. Over on the back the same hand had written this further information: Treasure Island. 12/30/2023 0 Comments Fire emoji apple![]() Please contact the moderators of this subreddit if you have any questions or concerns. ![]() I am a bot, and this action was performed automatically. There is no other way to recover your account, other than through official channels. ![]() You may also contact Snapchat using this link. If your Snapchat account has been temp locked, you may try to unlock it at this link. While we have safeguards in place, they are not always as effective as we would like. We encourage you to report these scammers if they send you a message via any social media channels. Depicted as a red, orange, and yellow flickering flame. They can be used to describe someone who is on fire (e.g., 'She's on fire') or to show excitement (e.g., 'I'm so excited for. Shop en English Emoji Meaning Emoji Designs Technical Information Fire A flame, as produced when something is on fire. Fire emojis can represent passion, intensity, and heat. All scammers have one thing in common, their primary goal is your money, and they often will make their scam look much more legitimate than it is in order to accomplish their goal. On this page you can copy and paste all Fire Emojis like and save them as png image. You should be wary of anyone offering to have your account unlocked via Instagram, Telegram, WhatsApp, or anywhere else, as you will lose your account or money. Click this button and select the emoji that you just downloaded from this website. Navigate to your server settings and proceed to click the 'emoji' tab, you will notice a purple button that says 'upload emoji'. Please note, scammers on this subreddit are targeting our visitors for their gain. To upload the Fire emoji to your Discord server follow these simple steps. ![]() If you enjoyed Lara’s relentless killing sprees, then it’s certain you’ll love this one. Your approach to this game will define the story and impact the ending, giving Dishonored a great sense of replayability. Using supernatural abilities, you’ll be sneaking and slicing your way through a steam-punk city.
12/29/2023 0 Comments Live mas scholarship 2021 deadlineThe Live Mas Scholarship was established in 2014 by Taco Bell Foundation, Inc., with the goal of helping students pursue their educational dreams. The scholarship is open to legal residents of the fifty United States and the District of Columbia who are eighteen years of age or older at the time of application. The Live Mas Scholarship is an annual scholarship program that provides financial assistance to eligible students who are enrolled in or have been accepted to a two- or four-year accredited college or university in the United States. What are the benefits of the Live Mas Scholarship? The final step of the application process is to submit your official transcripts. You will also be required to write a personal essay and submit a resume. The online application will require you to provide personal information, including your contact information, educational background, and financial need. Once you have created an account, you will be able to access the online application. The first step to applying for the Live Mas Scholarship is to create an account on the official website. How to apply for the Live Mas Scholarship To be eligible, applicants must be 17 years of age or older and have a minimum GPA of 2.5. The Live Mas Scholarship is open to legal residents of the United States who are currently enrolled in an accredited post-secondary institution. Who is eligible for the Live Mas Scholarship? For more information about the scholarship and how to apply, visit the Taco Bell Foundation website. If you’re looking for ways to finance your higher education, the Live Mas Scholarship is a great option to consider. A committee of Taco Bell Foundation representatives reviews all applications and selects recipients based on these criteria. The Live Mas Scholarship is awarded based on academic achievement, community involvement, and financial need. ![]() The scholarship is renewable for up to four years of undergraduate study, provided the recipient maintains a minimum GPA of 2.5. The scholarship award can be used for tuition, books, fees, and on-campus room and board at the recipient’s chosen accredited institution. Applicants must also be enrolled or accepted for enrollment in an accredited post-secondary institution in the United States. ![]() To be eligible for the scholarship, applicants must be legal residents of the United States and have a minimum GPA of 2.5. The program was established in 2014 by Taco Bell Foundation and is open to all high school seniors and college students who are planning to enroll in an accredited post-secondary institution in the United States. The Live Mas Scholarship is a program that provides scholarships to eligible students who are planning to pursue a higher education. So whether you’re a photographer, musician, artist or filmmaker, apply now and let us help you take your career to the next level. If you’re passionate about your craft and want to help build a better future, we want to hear from you. That’s why, for the past few years, we’ve been committed to investing in up-and-coming talent through our Live Mas Scholarship. We know that creative minds will shape the future – but they need the right support to make their ideas a reality. After the verification is received, the checks are written and students receive the funds to help them pursue their education.The Live Mas Scholarship is back for 2022! And this year, we’re looking for the next generation of leaders in the creative industries. They are required to submit proof of registration in a degree program during the following academic year as well as proof of U.S. ![]() Winners are notified by mail and given instructions for claiming their award. The final list of scholarship winners is presented to the Mensa Foundation Board of Trustees, who certify the winners. The next highest scores receive awards of the next lower amounts, and so on until all the winners are chosen based on the judges’ scores. Each applicant can receive only one Mensa Foundation scholarship per year therefore, the winners are chosen beginning at the highest dollar amounts. National judgingįinally, the National Scholarship Chairs conduct additional rounds of judging to select the regional and national winners. ![]() These essays are then forwarded to the National Scholarship Chairs. Regional judges rank the local winners and nominate the best essays for regional and national awards. The regional chair arranges for all of the essays referred from local chapters to be judged a second time. Regional judgingĪt the regional level, the process is repeated. The Local Scholarship Chair refers the best local essays to the Regional Scholarship Chair for review. The essays are judged on content and also grammar, organization, and craftsmanship. American Mensa’s local chapters assemble judging teams of at least three members to review the applications. 12/29/2023 0 Comments Starcraft 2 zerg build order![]() It's a very powerful roach timing that will allow you to work on the fundamentals of playing zerg such as consistent injects, a macro cycle to keep you on track and a focus on creating and managing your economy instead of focusing on the fights. This one is orientated towards brand new zerg players. You get right into the action super fast and it's very difficult for protoss to defend your first push never mind the second one.īeginner Friendly Zerg Build Order (vs all races) ZvX Timing Attack by hushang HuShang's 3rax Stim-Combat-Concussive Push This is a super strong & really fun build order that I've been playing in my TvP's almost exclusively. HuShang's 3rax SCC Push TvP Timing Attack by hushang It's a timing attack with plenty of roaches! Very easy beginner zerg build order that will work well from Bronze through to Platinum. HuShang's Beginner Zerg Build Order (2022) ZvX Timing Attack by hushang Lately blink attacks tend to lead to stale mid-games, but this build really spices things up and leads to a lot of chaos and aggression quite quickly :) ![]() Oracle/gateway timing attack that sets you up for a very fun/dynamic mid-game. HuShang's Oracle 3 Gate Attack PvT Timing Attack by hushang Very Standard Reaper Hellion Opening that transitions into Marine-Tank-Raven. Standard Terran vs Terran (3 Reaper 2 Hellion) TvT Economic by hushang Continued abuse of our services will cause your IP address to be blocked indefinitely.Secure Easy Wins with Astrea's PvZ Blink All-in PvZ All-In by ESChampĭo you want to dominate the Protoss vs Zerg early game and secure a win before the mid-game? Look no further than this 2 base blink all-in from Astrea. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. As one of the most well known early game Zerg cheese builds, bane bust is a great way to kill Terrans before they get too big.
![]() ![]() Its current limitations include a relatively small field of view, inability to show leakage, and proclivity for image artifact due to patient movement/blinking. OCTA is quick and non-invasive, and provides volumetric data with the clinical capability of specifically localizing and delineating pathology along with the ability to show both structural and blood flow information in tandem. Finally we summarize its potential application to retinal vascular diseases. In this paper, we introduce the technology, review the available English language publications regarding OCTA, and compare it with the current angiographic gold standards, fluorescein angiography (FA) and indocyanine green angiography (ICGA). At present, level 1 evidence of the technology’s clinical applications doesn’t exist. This is a nascent technology with a potential wide applicability for retinal vascular disease. The software is currently used as an offline tool for research purposes however, the software's embedded algorithms may also be useful for real-time treatment planning.Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging technique that generates volumetric angiography images in a matter of seconds. We introduced and evaluated the clinical application of a highly automated software package, OCTOPUS, for quantitative plaque and stent analysis in IVOCT images. Regarding stent analysis, sensitivity and precision were both greater than 90%, and each strut was successfully classified as either covered or uncovered with high sensitivity (94%) and specificity (90%). Only up to 3.8% of plaque pixels were modified, leading to an average editing time of only 7.5 seconds/frame, an approximately 80% reduction compared to manual analysis. Using OCTOPUS on 34 new pullbacks, we determined that following automated segmentation, only 13% and 23% of frames needed any manual touch up for detailed lumen and calcification labeling, respectively. Underlying plaque segmentation algorithm yielded excellent pixel-wise results (86.2% sensitivity and 0.781 F1 score). Interactive visualizations include (x,y) anatomical, en face, and longitudinal views with optional overlays. Quantifications include stent deployment characteristics (e.g., stent strut malapposition), strut level analysis, calcium angle, and calcium thickness measurements. Interactive visualization and manual editing of segmentations were included in the software. To automate image analysis results, the software includes several important algorithmic steps: pre-processing, deep learning plaque segmentation, machine learning identification of stent struts, and registration of pullbacks. To aid IVOCT research studies, we developed the Optical Coherence TOmography PlaqUe and Stent (OCTOPUS) analysis software. Download a PDF of the paper titled OCTOPUS - optical coherence tomography plaque and stent analysis software, by Juhwan Lee and 10 other authors Download PDF Abstract:Compared with other imaging modalities, intravascular optical coherence tomography (IVOCT) has significant advantages for guiding percutaneous coronary interventions. In this situation, we will advise you immediately. We also reserve the right to refuse to match a price in situations where competitors have made errors in their advertisements or are selling far below cost. vendors and does not apply to open box, factory seconds, discontinued or floor/demo products. 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